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King of Chemicals Manufacturers Phenylephrine Hydrochloride or Phenylephrine HCl and API BP Ph Eur EP USP NF IP JP ChP PPRC Reagent FCC Food Grade Manufacturer |
Specifications, Properties, Uses, SDS of Phenylephrine Hydrochloride or Phenylephrine HCl BP Ph Eur EP USP Grade Manufacturer Supplier Exporter Wholesale & Small Packs, CAS Number 61-76-7. | |
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Muby Chem Pvt. Ltd. is a several decades old group of companies, engaged in manufacturing, supplying, distributing, wholesale supplies of Phenylephrine Hydrochloride or Phenylephrine HCl BP Ph Eur EP USP Grade for actual users, including retail or small pack supplies for research and development work.
We supply fine and speciality chemicals, pharmaceutical excipients, mineral fortifiers in chemically pure, analytical reagent grade, API IP BP USP Ph Eur EP JP ChP PPRC and other pharmaceutical grade monograph including FCC Food grade chemicals and Nutraceuticals at best prices. We and/or our associated units have all the facilities to supply as per cGMP standard observing good manufacturing practice and good laboratory practice. We can assure low microbial count and also offer a test certificate for the same. We maintain warehouses across USA, India, and UAE. Our group exports to USA, Canada, Mexico, Argentina, Brazil, Chile, Korea, Malaysia, Thailand, Indonesia, Europe, and several other parts of the world. We supply in wholesale container loads to small pack of few grams. Solid products may be specified for it size and shape as desired by the buyer.
Phenylephrine Hydrochloride or Phenylephrine HCl CAS Number 61-76-7
For Properties Specifications Uses of Phenylephrine Hydrochloride or Phenylephrine HCl Click Properties, Specifications, Uses, Price, Process of Phenylephrine Hydrochloride or Phenylephrine HCl Manufacturer.
For For SDS MSDS Sheet of Phenylephrine Hydrochloride or Phenylephrine HCl Click SDS Safety Data Sheet MSDS Sheet of Phenylephrine Hydrochloride or Phenylephrine HCl Manufacturer.
The Properties, Specifications, Monograph and Uses of Phenylephrine Hydrochloride or Phenylephrine HCl:
Phenylephrine Hydrochloride is a versatile sympathomimetic medication that primarily acts as a selective alpha-1 adrenergic receptor agonist. By directly stimulating these receptors, it causes the blood vessels to narrow. It is used in Nasal Decongestion, Eye Drops, Intravenous Vasopressor, Anorectal Care, etc.
Phenylephrine Hydrochloride BP Ph Eur Grade:
C9H14ClNO2 --- 203.7 CAS 61-76-7
Action and use: Alpha-adrenoceptor agonist.
DEFINITION
(1R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethanol hydrochloride.
Content: 98.5 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Freely soluble in water and in ethanol (96 per cent).
Melting Point: About 143C.
IDENTIFICATION
First identification: A, C, E
Second identification: A, B, D, E
A. Specific optical rotation
B. Melting point: 171C to 176C.
Dissolve 0.3 g in 3 mL of water, add 1 mL of dilute ammonia and nitiate crystallization by scratching the wall of the tube with a glass rod. Wash the crystals with iced water and dry at 105C for 2 h.
C. Infrared absorption spectrophotometry.
D. Dissolve about 10 mg in 1 mL of water and add 0.05 mL of a 125 g/L solution of copper sulfate pentahydrate and 1 mL of a 200 g/L solution of sodium hydroxide. A violet colour is produced. Add 1 mL of ether and shake; the upper layer remains colourless.
E. It gives reaction (a) of chlorides.
TESTS
Solution S: Dissolve 2.00 g in carbon dioxide-free water prepared from distilled water and dilute to 100.0 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
Acidity or alkalinity: To 10 mL of solution S add 0.1 mL of methyl red solution and 0.2 mL of 0.01 M sodium hydroxide. The solution is yellow. Not more than 0.4 mL of 0.01 M hydrochloric acid is required to change the colour of the indicator to red.
Specific optical rotation: -43 to -47 (dried substance), determined on solution S.
Related substances: To pass the test by Liquid chromatography.
Sulfates: Maximum 500 ppm, determined on solution S.
Loss on drying: Maximum 1.0 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Phenylephrine Hydrochloride USP Grade Specifications:
C9H13NO2-HCl --- 203.67
Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, hydrochloride (R)-;
(−)-m-Hydroxy-α-[(methylamino)methyl]benzyl alcohol hydrochloride
CAS 61-76-7
UNII: 04JA59TNSJ
UNII: 1WS297W6MV
DEFINITION
Phenylephrine Hydrochloride contains NLT 98.0% and NMT 102.0% of phenylephrine hydrochloride (C9H13NO2-HCl), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption.
B. Identification Tests—General, Chloride.
C. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Assay: 98% to 102%
Residue on Ignition: NMT 0.2%
Chloride and Sulfate:
Standard solution: 0.10 mL of 0.020 N sulfuric acid
Sample solution: 50 mg in 25 mL of water
Acceptance criteria: The Sample solution shows no more turbidity than corresponds to that of the Standard solution (0.20%).
Organic Impurities: To pass the test by chromatography.
Optical Rotation, Specific Rotation:
Sample solution: 50 mg/mL in water
Acceptance criteria: −43° to −47°
Loss on Drying: Dry at 105° for 2 h. Acceptance criteria: NMT 1.0%
Packaging and Storage: Preserve in tight, light-resistant containers. Store at 25°, excursions permitted between 15° and 30°.
We also manufacture Phenylephrine Hydrochloride or Phenylephrine HCl EP Grade.
The MSDS-SDS Hazard Statement of Phenylephrine Hydrochloride or Phenylephrine HCl:
Phenylephrine Hydrochloride or Phenylephrine HCl SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Product Name & Other Names: Phenylephrine Hydrochloride or Phenylephrine HCl.
CAS No.: 61-76-7
EINECS EC Number: 200-517-3
Molecular Formula: HOC6H4CH(CH2NHCH3)OH-HCl or C9H13NO2-HCl,
Molecular Weight: 203.67
Relevant uses and uses advised against (if any): Laboratory and Industrial Use.
Supplier: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral (Category 4) H302
Skin sensitization (Category 1), H317
Labeling according to GHS USA & Regulation (EC) No 1272/2008
GHS Label Elements Harmful |
Signal Words: Danger
Hazard Statements:
H302: Harmful if swallowed.
H317: May cause an allergic skin reaction.
Precautionary Statements:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash contaminated parts thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310: IF SWALLOWED: Immediately call a POSION CENTER or doctor/physician.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.
P403+233+235: Store in a well-ventilated place. Keep container tightly closed. Keep cool.
3. Composition/Information on Ingredients
Product Name & Other Names: Phenylephrine Hydrochloride or Phenylephrine HCl.
CAS No.: 61-76-7
EINECS EC Number: 200-517-3
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim inhaled the substance. Induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Get medical attention.
Ingestion: Rinse mouth. Do not induce vomiting without medical advice. If vomiting occurs naturally, have victim lean forward to reduce the risk of aspiration. Never give anything by mouth to a victim who is unconscious or is having convulsions. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Use a mild soap if available. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reusing. Thoroughly clean shoes before reusing them. For minor skin contact, avoid spreading material on unaffected skin.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Products of Combustion: Carbon oxides, nitrogen oxides, Chlorine compounds and fumes.
Fire Extinguishing Media: Water spray. Alcohol foam. Polymer foam. Dry chemical powder. Carbon dioxide (CO2). Avoid a solid water stream as it may scatter and spread fire. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations. In the event of fire and/or explosion do not breathe fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment, cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep up and move to an approved disposal container.
7. Handling and Storage
Precautions for safe handling: Do not handle or store near an open flame, heat, or other sources of ignition. All equipment used when handling the product must be grounded. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Room Temperature (Recommended in a cool and dark place, <15°C). Preferably refrigerate at 4C. Hygroscopic.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice.
9. Physical and Chemical Properties
Appearance: Odorless white microcrystalline powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: No data found.
Relative density: No data found.
Melting point/freezing point: 140C to 145C literature.
Initial boiling point and boiling range: No data found.
Flash point: No data found.
Auto-ignition temperature: No data found.
Decomposition temperature: No data found.
Upper/lower flammability or explosive limits: No data found.
Vapor pressure: No data found.
Vapor density: No data found.
Evaporation rate: No data found.
Flammability (solid, gas): No data found.
Partition coefficient: n-octanol/water: No data found.
Solubility(ies): Soluble in water and in ethanol (96 per cent).
Viscosity: No data found.
10. Stability and Reactivity
Stability: It is stable under recommended conditions of use and storage.
Hazardous Decomposition Products: It emits carbon oxides, nitrogen oxides, chlorine compounds and toxic fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents. Acids.
Conditions to Avoid: Avoid light, heat, sparks, open flames, and other ignition sources. Contact with incompatible materials.
11. Toxicological Information
Toxicity data:
LD50 Oral - Rat – 350. mg/kg
Carcinogenicity: Not expected to be hazardous by IARC, OSHA, ACGIH and NTP criteria.
Mutagenic Effects: No data found.
Reproductive Effects: No data found.
Developmental Effects: No data found.
Teratogenicity: No data found.
12. Ecological Information
Toxicity to daphnia and other aquatic invertebrates: static testEC50 - Daphnia magna (Water flea) - 4,59 mg/l - 48 h.
Persistence and degradability: Unlikely to persist due to water solubility.
Mobility in soil: Likely to be mobile due to water solubility.
Results of PBT and vPvB assessment: Not PBT and vPvB.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Dispose of containers and unused contents in accordance with federal, state, and local requirements. Follow all the pollution control rules.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IMDG/IMO: Not dangerous goods.
IATA: Not dangerous goods.
15. Regulatory Information
USA:
SARA 311/312 Hazards: See section 2.
California Prop. 65 Components: Not listed.
Section 16 - Additional Information
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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Phenylephrine Hydrochloride or Phenylephrine HCl Manufacturers, Suppliers, Exporters, Wholesalers:
King of Chemicals manufacturers
Plot No. 2900/46&47 + 2900/163to167, GIDC, Ankleshwar, Dist. Bharuch, India
India, USA, UAE
TEL: (Office) 91-22-65290111
email: info@kingofchemicals.com
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Our products are for industrial and laboratory use only. The user must test the material before use. We are not despensing chemists or druggist and do not offer over the counter type (OTC) products for medical use by individuals.
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